A man has died in a crash between a car and a prime mover on the Warrego Highway, west of Toowoomba.


Police said the car and the prime mover collided about two kilometres west of Bowenville, about 180 kilometres west of Brisbane, about 12.25am on Tuesday.


The sedan driver died at the scene while the prime mover driver was not injured.


A police spokeswoman said the two vehicles were travelling in opposite directions before the crash.


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The Warrego Highway has been closed with westbound traffic diverted via Bowenville-Norwin Road. Eastbound traffic has been diverted at the Dalby-Cecil Plains turnoff.


Queensland Police’s forensic crash unit will continue to investigate the crash on Tuesday.


Anyone with information should contact Crime Stoppers on 1800 333 000.